Product Specifications
| Specification | Details |
| Manufacturer / Brand | Pfizer Pharmaceuticals / Solu-Medrol® |
| Manufacturer # / SKU | 00009004722 |
| NDC Number | 00009-0047-22 |
| Active Ingredient | Methylprednisolone Sodium Succinate |
| Strength | 125 mg / 2 mL |
| Formulation | Preservative-Free, Sterile Powder for Injection |
| Container Type | Act-O-Vial® (Dual-Chamber Vial) |
| Route of Admin | IV (Intravenous) or IM (Intramuscular) |
| Packaging | 25 Vials per Carton |
| Storage | Controlled Room Temperature (20°C to 25°C) |
Key Features
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Act-O-Vial® System: Simplifies the reconstitution process; simply press down on the plastic activator to mix the diluent with the powder, eliminating the need for separate vials and syringes for mixing.
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Rapid Anti-Inflammatory Action: Highly soluble ester provides immediate onset of action, critical for treating life-threatening allergic or inflammatory episodes.
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Preservative-Free: Suitable for patients with sensitivities to common preservatives like benzyl alcohol (though check specific labeling for pediatric use).
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Versatile Delivery: Can be administered via IV injection, IV infusion, or IM injection depending on the clinical urgency and patient condition.
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Precision Dosing: The 125 mg/2 mL strength is optimized for standard adult doses and pediatric weight-based protocols.
Clinical Applications
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Acute Exacerbations: Treatment of acute flares in Multiple Sclerosis or Rheumatic disorders.
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Severe Allergic Reactions: Management of anaphylaxis, status asthmaticus, or drug hypersensitivity.
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Critical Care: Adjunctive therapy in certain life-threatening conditions or shock.
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Dermatologic Conditions: Treatment of severe erythema multiforme (Stevens-Johnson syndrome).
⚠️ Reconstitution Note: Use the solution within 48 hours after mixing. The reconstituted solution should be clear; do not use if it is cloudy or contains particulates.
⚠️ Safety Alert: Not for use by the intrathecal route of administration. Monitor for hypertension, sodium retention, and potential psychiatric disturbances during therapy.
⚠️ Contraindications: Contraindicated in patients with systemic fungal infections or known hypersensitivity to methylprednisolone.
